As interest in cannabidiol (CBD) continues to soar, an increasing variety of CBD products are flooding the market, offering consumers a wealth of options for incorporating CBD into their wellness routines. From oils and tinctures to edibles and topicals, the diversity of CBD products can be overwhelming for beginners and experienced users alike. In this blog, we’ll embark on a journey to explore the different types of CBD products available, their unique characteristics, and their potential uses in promoting health and well-being.
Types of CBD Products explores the diverse array of cannabidiol-infused offerings available to consumers, ranging from oils and tinctures to edibles, topicals, capsules, and more. This comprehensive guide delves into the unique characteristics, uses, and benefits of each CBD product category, empowering users to make informed choices and discover the ideal CBD solution for their wellness needs.
Also Read: CBD Oil for Menstrual Pain Relief
CBD oils and tinctures are among the most popular and versatile forms of CBD products. Typically administered sublingually, these liquid formulations are absorbed quickly into the bloodstream, offering fast-acting relief. They come in various concentrations, allowing users to adjust their dosage according to their needs. CBD oils and tinctures are commonly used for promoting relaxation, managing stress, and supporting overall wellness.
CBD edibles encompass a wide range of products, including gummies, chocolates, capsules, and beverages infused with CBD. These delicious and convenient options provide a discreet way to consume CBD, making them ideal for on-the-go use. CBD edibles offer long-lasting effects, as they are metabolized in the digestive system. They are often used for promoting calmness, enhancing mood, and supporting a restful sleep.
CBD topicals are applied directly to the skin and are designed to target localized areas of discomfort or inflammation. These products include creams, lotions, balms, and salves infused with CBD, as well as transdermal patches and bath bombs. CBD topicals are commonly used for relieving muscle tension, soothing sore joints, and supporting skin health.
CBD capsules and pills are pre-measured doses of CBD enclosed in a convenient oral form. These products offer a precise and consistent dosage, making them suitable for users who prefer a standardized approach to CBD consumption. CBD capsules and pills are often used for managing chronic pain, reducing inflammation, and promoting relaxation.
CBD vapes and inhalables deliver CBD directly into the bloodstream through inhalation. These products include vape oils, cartridges, concentrates, and inhalable powders. Inhalable CBD offers rapid absorption and immediate effects, making it a popular choice for users seeking fast relief from symptoms such as anxiety or acute pain.
The wide variety of CBD products available reflects the growing interest and demand for cannabidiol as a natural wellness remedy. Whether you prefer the convenience of oils and tinctures, the deliciousness of edibles, the targeted relief of topicals, or the fast-acting effects of inhalables, there’s a CBD product to suit every preference and lifestyle. By exploring the different types of CBD products and their uses, consumers can find the perfect CBD solution to support their health and well-being goals.
Menstrual pain, often referred to as dysmenorrhea, affects millions of women worldwide, causing discomfort, cramps, and mood swings. While traditional remedies like painkillers can provide relief, many are turning to more natural alternatives like CBD oil. In this comprehensive guide, we’ll explore the potential benefits of CBD oil for menstrual pain relief and how it works to alleviate discomfort during menstruation.
Before delving into the benefits of CBD oil, it’s crucial to understand the nature of menstrual pain. Dysmenorrhea can be categorized as primary or secondary. Primary dysmenorrhea occurs due to natural menstrual cycles and is characterized by uterine contractions, while secondary dysmenorrhea is linked to underlying health conditions like endometriosis or fibroids.
Many women rely on over-the-counter pain relievers like ibuprofen or acetaminophen to manage menstrual cramps. While these medications can be effective, they may come with side effects and risks, especially with prolonged use. CBD oil, derived from the cannabis plant, offers a natural alternative without the psychoactive effects associated with THC.
CBD interacts with the body’s endocannabinoid system (ECS), which plays a crucial role in regulating various bodily functions, including pain perception and inflammation. By targeting cannabinoid receptors in the ECS, CBD oil can help alleviate pain and discomfort associated with menstruation. Additionally, CBD possesses anti-inflammatory properties that can reduce swelling and inflammation in the pelvic area.
While research on CBD specifically for menstrual pain is limited, several studies have investigated its effectiveness in managing chronic pain and inflammation. A 2015 review published in the Journal of Neuroimmune Pharmacology suggested that CBD could modulate pain perception and reduce inflammation through its interaction with cannabinoid receptors.
Furthermore, a 2019 study published in the Journal of Clinical Investigation found that CBD could reduce both inflammation and neuropathic pain associated with conditions like arthritis. While these studies focus on chronic pain rather than menstrual pain specifically, their findings support the potential benefits of CBD for managing pain and inflammation.
In addition to scientific research, many women have reported positive experiences with using CBD oil for menstrual pain relief. Personal testimonials often highlight CBD’s ability to provide quick and effective relief from cramps and discomfort without the side effects commonly associated with traditional painkillers.
When using CBD oil for menstrual pain relief, it’s essential to start with a low dosage and gradually increase until you find the optimal level for your needs. CBD oil can be consumed orally, sublingually, or topically. Sublingual administration, where the oil is held under the tongue for faster absorption, is often preferred for quicker relief. However, topical applications like CBD-infused creams or balms can also provide targeted relief to the affected area.
With the growing popularity of CBD, it’s essential to choose high-quality products from reputable manufacturers. Look for CBD oils that are derived from organically grown hemp and undergo third-party testing for purity and potency. Additionally, opt for full-spectrum CBD oils, which contain a wide range of cannabinoids, terpenes, and other beneficial compounds that work synergistically to enhance the oil’s effectiveness.
While CBD is generally well-tolerated, some individuals may experience side effects such as drowsiness, dry mouth, or changes in appetite. It’s crucial to consult with a healthcare professional before incorporating CBD oil into your menstrual pain management routine, especially if you’re pregnant, breastfeeding, or taking other medications.
CBD oil offers a promising natural alternative for women seeking relief from menstrual pain and discomfort. Its ability to modulate pain perception, reduce inflammation, and provide relaxation makes it a valuable addition to the toolkit for managing period symptoms. However, more research is needed to fully understand the efficacy and safety of CBD for menstrual pain relief. By choosing high-quality products and consulting with healthcare professionals, women can harness the potential benefits of CBD oil to alleviate period-related discomfort and improve their overall quality of life.
In the ever-evolving landscape of cannabis cultivation, Best high CBD seeds have emerged as a beacon of hope for those seeking natural remedies for various ailments. As society becomes increasingly health-conscious, the demand for CBD-rich strains continues to surge. But what exactly are high CBD seeds, and how do they unlock the healing potential of cannabis? Let’s delve into this fascinating world and explore the medicinal benefits these seeds offer.
Before diving into their medicinal benefits, it’s crucial to grasp what high CBD seeds are and how they differ from their high THC counterparts. CBD, short for cannabidiol, is one of the many cannabinoids found in the cannabis plant. Unlike THC (tetrahydrocannabinol), CBD is non-psychoactive, meaning it doesn’t induce the “high” typically associated with cannabis use. High CBD seeds are specifically bred to produce plants with elevated levels of CBD and minimal THC content, making them ideal for medicinal purposes.
One of the most well-known medicinal benefits of CBD is its ability to alleviate pain and reduce inflammation. Numerous studies have shown that CBD interacts with the body’s endocannabinoid system, which plays a crucial role in regulating pain sensation. From chronic conditions like arthritis to acute injuries, high CBD strains offer a natural alternative to traditional painkillers with fewer side effects.
In today’s fast-paced world, anxiety and stress have become prevalent issues affecting millions of people worldwide. Fortunately, CBD has shown promise as an effective remedy for anxiety disorders and stress-related symptoms. By modulating neurotransmitter activity in the brain, CBD can promote feelings of relaxation and calmness without the intoxicating effects of THC.
Another area where high CBD seeds shine is in their neuroprotective properties. Research suggests that CBD may help protect neurons from damage and degeneration, making it a potential therapeutic option for neurodegenerative diseases like Alzheimer’s and Parkinson’s. Additionally, CBD’s anti-inflammatory effects may contribute to overall brain health and cognitive function.
Perhaps one of the most well-documented medicinal applications of CBD is in the treatment of epilepsy and seizure disorders. In fact, the FDA has approved a CBD-based medication called Epidiolex for the treatment of certain types of seizures. High CBD strains offer hope to patients who have not responded well to traditional antiepileptic drugs, providing a natural alternative with fewer adverse effects.
Quality sleep is essential for overall health and well-being, yet many people struggle with sleep disorders like insomnia and sleep apnea. CBD may offer relief for individuals experiencing sleep disturbances by promoting relaxation and reducing anxiety levels. High CBD strains with calming effects can help improve sleep quality and duration, leading to a more restful night’s sleep.
Now that we’ve explored the myriad medicinal benefits of high CBD seeds, you may be wondering how to incorporate them into your garden. Fortunately, cultivating these strains is relatively straightforward, especially with the wealth of resources and information available to today’s growers.
When selecting high CBD seeds, it’s essential to choose reputable breeders known for their commitment to quality and consistency. Look for strains with a balanced CBD to THC ratio and consider factors like growing environment, flowering time, and desired effects.
Once you’ve acquired your high CBD seeds, proper cultivation techniques are key to maximizing their medicinal potential. Ensure your plants receive adequate sunlight, water, and nutrients throughout their growth cycle, and monitor for any signs of pests or diseases.
In conclusion, high CBD seeds offer a wealth of medicinal benefits that have the potential to transform lives and improve overall well-being. From pain management and anxiety relief to neuroprotection and sleep enhancement, CBD-rich strains hold promise as natural remedies for a wide range of ailments.
As society continues to embrace the therapeutic potential of cannabis, high CBD seeds will undoubtedly play a central role in the future of medicinal cannabis cultivation. By unlocking the healing potential of these seeds, we can cultivate wellness and vitality for ourselves and future generations.
In recent years, there has been a surge in interest surrounding cannabinoids and their potential health benefits. While CBD (cannabidiol) has dominated the spotlight for its various therapeutic properties, another cannabinoid called CBG (cannabigerol) is starting to gain attention for its potential role in improving sleep quality. In this article, we will delve into the science behind CBG oil and its effects on sleep, exploring its mechanisms of action and the available research on its efficacy.
CBG, like CBD, is a non-psychoactive cannabinoid found in the cannabis plant. It is often referred to as the “mother cannabinoid” because it is the precursor to other cannabinoids such as THC and CBD. Although CBG is present in smaller quantities compared to CBD and THC, researchers are increasingly interested in its potential therapeutic effects.
CBG interacts with the endocannabinoid system (ECS), a complex network of receptors and neurotransmitters that play a crucial role in regulating various physiological processes, including sleep. Through its interaction with the ECS, CBG may modulate neurotransmitter release, reduce inflammation, and promote relaxation, all of which are essential for a restful night’s sleep.
While research specifically focusing on CBG’s effects on sleep is limited, several studies have investigated its potential therapeutic properties. A study published in the Journal of Pharmacology and Experimental Therapeutics found that CBG exhibited sedative effects in mice, suggesting its potential as a sleep aid. Additionally, a 2018 review published in the Cannabis and Cannabinoid Research journal highlighted CBG’s anti-inflammatory and analgesic properties, which could indirectly contribute to improved sleep quality by reducing pain and discomfort.
Although scientific evidence on CBG’s effects on sleep is still emerging, many individuals have reported positive experiences with CBG oil for sleep issues. Users have noted that CBG oil helps them relax before bedtime, reduces anxiety, and promotes a deeper, more restorative sleep. However, it’s essential to recognize that anecdotal evidence is subjective and may not always reflect scientific findings.
Based on its pharmacological properties and anecdotal reports, CBG oil may offer several potential benefits for improving sleep quality:
Like CBD, CBG is generally well-tolerated and considered safe for consumption. However, individual responses to cannabinoids may vary, and some users may experience side effects such as dry mouth, dizziness, or changes in appetite. It’s essential to start with a low dose of CBG oil and gradually increase as needed while monitoring for any adverse reactions.
While further research is needed to fully understand CBG’s effects on sleep, emerging evidence suggests that it may hold promise as a natural sleep aid. Its interaction with the endocannabinoid system and potential therapeutic properties make it an intriguing subject for future studies. If you’re considering trying CBG oil for sleep issues, consult with a healthcare professional to determine the appropriate dosage and ensure its compatibility with your individual needs and medical history. With cautious use and ongoing research, CBG oil could offer a new avenue for promoting restful sleep and improving overall well-being.
With the growing interest in cultivating cannabis for personal or medicinal use, many individuals are opting to grow their own plants indoors. Starting from seeds can be an exciting and rewarding journey, but it requires careful attention to detail to ensure successful growth. In this guide, we’ll walk you through the steps of planting cannabis seeds indoors, from selecting the right seeds to providing the optimal growing conditions for healthy plant development.
Before diving into the planting process, it’s essential to choose high-quality cannabis seeds. Factors to consider when selecting seeds include genetics, strain type, and desired effects. Whether you’re looking for a high-THC strain for recreational use or a CBD-rich variety for medicinal purposes, research different strains to find the one that best suits your needs.
Additionally, ensure that you acquire seeds from a reputable source to guarantee their authenticity and viability. Look for trusted seed banks or dispensaries with a track record of providing quality seeds to avoid potential issues during the cultivation process.
Creating an optimal growing environment is crucial for the successful cultivation of cannabis indoors. Start by setting up a dedicated grow space that offers sufficient room for your plants to thrive. Consider factors such as lighting, ventilation, temperature, and humidity control.
Investing in proper lighting is essential for promoting healthy growth during the seedling stage. While natural sunlight is ideal, many growers opt for artificial lighting options such as LED, HPS, or fluorescent grow lights. Ensure that your chosen lighting system provides the appropriate spectrum and intensity for seedling development.
Maintaining proper ventilation helps prevent issues such as mold and mildew while ensuring adequate airflow for optimal plant growth. Use exhaust fans, air filters, and oscillating fans to regulate airflow and maintain consistent environmental conditions.
Temperature and humidity play a critical role in cannabis cultivation, especially during the seedling stage. Aim for a temperature range of 70-85°F (21-29°C) and a relative humidity level of 50-70% to create a favorable environment for seed germination and early growth.
Once you’ve prepared your growing environment, it’s time to plant your cannabis seeds. Follow these steps for successful seedling establishment:
Once your cannabis seeds have germinated and seedlings have emerged, it’s crucial to monitor their progress and provide appropriate care. Keep an eye on the following factors:
Expanding on the intricacies of planting cannabis seeds indoors, let’s delve deeper into each stage of the process and explore additional considerations for optimal growth and development.
While the paper towel method and water soaking are popular germination techniques, growers can also consider alternatives such as using seedling plugs or germination cubes. These methods offer convenience and reduce the risk of damaging delicate seedlings during the transfer process.
In addition to traditional seedling trays, growers may opt for biodegradable pots or fabric pots, which promote healthy root development and can be transplanted directly into larger containers later in the growth cycle. Choosing the right medium is crucial, with options ranging from coco coir and peat moss to soilless mixes and hydroponic systems. Each medium has its advantages and requires specific care considerations, so research and experimentation are key to finding the best fit for your growing setup.
While artificial lighting is essential for indoor cannabis cultivation, the choice between different lighting options can be daunting for beginners. LED grow lights are energy-efficient and offer a full spectrum of light for all growth stages, while HPS lights provide intense light output ideal for flowering. Fluorescent lights, such as T5 or CFL bulbs, are cost-effective options for seedling and vegetative growth stages. Experimenting with light intensity and distance from plants can help optimize growth and prevent issues such as stretching or light burn.
Overwatering is a common pitfall for novice growers, leading to root suffocation and nutrient leaching. To avoid this, consider using bottom watering techniques or self-watering systems that deliver moisture directly to the root zone without saturating the soil surface. Additionally, monitoring soil moisture levels with a moisture meter or by simply feeling the soil’s texture can help determine when watering is necessary.
While cannabis seedlings require minimal nutrients initially, transitioning to a comprehensive feeding schedule as plants mature is essential for maximizing yield and potency. Utilizing organic fertilizers or nutrient solutions tailored to cannabis cultivation ensures balanced nutrition without the risk of nutrient burn or toxicity. Pay attention to pH levels in the growing medium, as imbalances can interfere with nutrient uptake and lead to nutrient deficiencies or lockout.
As seedlings mature into vegetative growth, employing training techniques such as topping, low-stress training (LST), or defoliation can encourage bushier growth and maximize light penetration. These methods help control plant height and shape, increasing overall yield and promoting even canopy development. However, it’s crucial to exercise caution and avoid excessive stress that could hinder plant health and productivity.
Investing in environmental monitoring equipment such as hygrometers, thermometers, and CO2 monitors allows growers to maintain optimal conditions throughout the entire growth cycle. Automated systems for temperature and humidity control, as well as carbon dioxide supplementation, can help fine-tune environmental parameters and mitigate stressors that impact plant health and productivity.
Planting cannabis seeds indoors can be a rewarding experience for both novice and experienced growers alike. By selecting high-quality seeds, creating a suitable growing environment, and providing attentive care, you can nurture healthy seedlings and ultimately harvest your own cannabis crop. With patience, dedication, and a bit of knowledge, you’ll be well on your way to enjoying the fruits of your labor.
Autoflowering cannabis seeds have gained immense popularity among both novice and experienced cannabis growers in recent years. These seeds offer a unique set of advantages that make them a preferred choice for many cultivators. In this comprehensive guide, we will delve into the fascinating world of autoflowering cannabis seeds, exploring their benefits, characteristics, and how to maximize your yields when growing them.
Unlocking the advantages of autoflowering cannabis seeds can revolutionize your cultivation experience. Their speed, resilience, and compact size make them a fantastic choice for both beginners and seasoned growers. By selecting the right strain and carefully managing your grow, you can enjoy consistent, high-quality yields throughout the year. Whether you’re looking for a discreet, low-maintenance option or want to explore a new dimension of cannabis cultivation, autoflowering seeds offer a world of possibilities. So, give them a try and experience the benefits of this remarkable cannabis variety for yourself. Happy growing!
The popularity of Cannabis has surged in recent years, thanks to its potential health benefits and non-intoxicating properties. Many individuals are now interested in growing their own CBD-rich cannabis plants. To embark on this journey successfully, it’s essential to understand the basics of Cannabis seeds, cultivation, and the optimal harvest season. In this comprehensive guide, we’ll delve into Cannabisseeds, the cultivation process, and the ideal time for harvesting your CBD-rich cannabis plants.
CBD seeds, also known as hemp seeds, are the starting point for growing CBD-rich cannabis plants. These seeds are specifically bred to produce plants with high Cannabis content and minimal levels of tetrahydrocannabinol (THC), the psychoactive compound found in cannabis. Selecting the right Cannabis seeds is crucial to ensure a successful and legal cultivation process.
There are various types of Cannabis seeds available, depending on your preferences and goals:
When acquiring Cannabis seeds, it’s essential to purchase them from reputable seed banks or breeders. Look for seeds with clear documentation of CBD and THC levels, as well as any additional information about the strain’s characteristics. Legitimate sources will provide this information to help you make an informed choice.
The first step in cultivating CBD-rich cannabis plants is germination. Here’s how to get started:
Selecting the right growing medium is crucial for the health and growth of your Cannabis plants. Common options include:
Cannabis plants require specific light and temperature conditions for optimal growth:
Proper nutrition and hydration are essential for your Cannabis plants. Invest in high-quality nutrients designed for cannabis cultivation and monitor your plants for signs of nutrient deficiencies or overfeeding. Water your plants when the top inch of soil feels dry, ensuring they receive adequate hydration without becoming waterlogged.
To maximize Cannabis production, consider pruning and training your plants:
Monitor your Cannabis plants regularly for signs of pests or diseases. Preventative measures like using neem oil or introducing beneficial insects can help protect your crop. Early detection and treatment are crucial to maintaining plant health.
Maintaining the correct pH level of your growing medium is essential for nutrient absorption. Regularly test the pH of your soil or hydroponic solution and adjust it as needed to keep it within the optimal range for cannabis cultivation, typically between 6.0 and 7.0.
The optimal time to harvest your CBD-rich cannabis plants is a critical factor in determining the quality and potency of your yield. Harvest timing primarily depends on the maturity of the trichomes, which are the resin glands containing Cannabis and other cannabinoids.
To assess trichome maturity, use a magnifying tool to examine the resin glands on the flowers:
Once you’ve determined that your trichomes are at the desired stage, it’s time to harvest your CBD-rich cannabis plants:
Proper drying and curing are crucial for preserving the quality and flavor of your Cannabis buds:
The ideal harvest season can vary based on whether you’re growing Cannabis plants outdoors or indoors:
Patience is key when it comes to harvesting CBD-rich cannabis plants. Rushing the harvest can result in lower Cannabis content and overall quality. Regularly monitor the trichomes and be prepared to wait for the optimal time.
As you embark on your journey to cultivate CBD-rich cannabis, keep these key takeaways in mind:
Cultivating CBD-rich cannabis plants is a rewarding endeavor that requires careful consideration of Cannabis seeds, cultivation techniques, and the timing of the harvest season. With the right knowledge and dedication, you can produce high-quality Cannabis products for personal use or even join the burgeoning Cannabis industry. Remember to always adhere to local laws and regulations regarding cannabis cultivation and use, and consult with experienced growers or professionals if you’re new to the process.
Hemp is an ancient plant that has been cultivated for millennia. The Columbia History of the World (1996) states that that weaving of hemp fiber began over 10,000 years ago! Carbon tests have suggested that the use of wild hemp dates as far back as 8000 B.C.
In Great Britain, hemp cultivation dates back to 800AD. In the 16th Century, Henry VIII encouraged farmers to plant the crop extensively to provide materials for the British Naval fleet. A steady supply of hemp was needed for the construction of battleships and their components. Riggings, pendants, pennants, sails, and oakum were all made from hemp fiber and oil. Hemp paper was used for maps, logs, and even for the Bibles that sailors may have brought on board.
17th Century America, farmers in Virginia, Massachusetts and Connecticut were ordered by law to grow Indian hemp. By the early 18th centuryC, a person could be sentenced to jail if they weren’t growing hemp on their land! Hemp was considered to be legal tender. For over 200 years in colonial America, hemp was currency that one could use to pay their taxes with! (Don’t try that today, kids!)
The 1850 U.S. census documented approximately 8,400 hemp plantations of at least 2000 acres. Strains in cultivation included China hemp, Smyrna hemp and Japanese hemp.
For years, hemp farmers used a hand break operated machine when harvesting. Finally a machine was built that would take care of all the processes, breaking the retted stalks and cleaning the fiber to produce clean, straight hemp fiber which was equal to the best grades prepared on hand brakes. This machine was able to harvest 1000 pounds or more of clean hemp fiber per hour. This breakthrough made cultivating more fiscally attractive by reducing labor costs. By 1920 the hemp crop was entirely handled by machinery.
In 1896 Rudolph Diesel had produced his famous engine. Like many others, Diesel assumed that the diesel engine would be powered by a variety of fuels, especially vegetable and seed oils. Henry Ford of the Ford Motor Company seeing the potential of biomass fuels operated a successful biomass conversion plant producing hemp fuel at their Iron Mountain facility in Michigan. Ford engineers extracted methanol, charcoal fuel, tar, pitch, ethyl acetate and creosote, fundamental ingredients for modern industry. Today these are supplied by oil-related industries.
Prohibition
Viewing hemp as a threat, a smear campaign against hemp was started by competing industries, associating hemp with marijuana.
Propaganda films like “Reefer Madness” assured hemp’s demise.
When Congress passed the Marijuana Tax Act in 1937, the decline of hemp effectively began. The tax and licensing regulations of the act made hemp cultivation nearly impossible for American farmers. Anslinger, the chief promoter of the Tax Act, argued for anti-marijuana legislation around the world.
An interesting situation arose during World War II as American Farmers were prohibited from producing hemp because of the 1937 law. However, the Japanese attack on Pearl Harbor halted the importation of Manila hemp from the Philippines, prompting the USDA to rethink their agenda and creating a call to action with the release of the film Hemp for Victory, motivating American Farmers to grow hemp for the war effort. The government formed a private company called War Hemp Industries to subsidize hemp cultivation. One million acres of hemp were grown across the Midwest as part of this program. As soon as the war ended, all of the hemp processing plants were shut down and the industry again disappeared. However, wild hemp may be found scattered across the country.
From 1937 until the late 1960s the United States government recognized that Industrial Hemp and marijuana were two distinct varieties of the cannabis plant. After the Controlled Substances Act was passed, hemp was no longer recognized as being distinct from marijuana.
Smoking has been around for a long time; not only is it an addiction, it is also a social activity- people enjoy the process of smoking: lighting up, watching the smoke, sharing smoking time with others. Even though they know the health risks, they still do it. They watch others die of lung cancer, heart disease and other smoking-related health issues, yet most smokers continue to light up. But what if there were an alternative, a way to get the enjoyment of smoking and yet lessen the detrimental effects?
There is, and it has a lot of names: Vape, vaping, vaporizing, E Cigarettes…
Regardless of what you call it, it’s a way to get the enjoyment of smoking with what is starting to look like a lot less health damage. Many smokers are finding vaping a great alternative to cigarette smoking, and with the availability of CBD oils, the alternative is better.
Tobacco smoke- loaded with tar.
Vaporized oil- no tar.
Tobacco- loaded with carcinogenic chemicals including formaldehyde, benzene, arsenic and MANY more. Most of these chemicals are known carcinogens.
CBD Vape Oil- CBD oil, glycerin, glycol, sometimes a flavoring. That’s it.
Tobacco/cigarette- a fire hazard. Fall asleep with a cigarette or drop a lit cigarette, you can start a fire.
Vape- the oil is heated inside a chamber. There is no actual fire burning and the heating element is enclosed in the e-cigarette or vaporizer.
Cigarettes cost from $6 to $15 a pack, making smoking an expensive as well as unhealthy habit; vaping is a significantly cheaper activity.
If you’re looking to get off cigarettes, we can help. Try our line of CBD vape oils and replace tobacco and its long list of carcinogens with what’s appearing to be a promising alternative that just might promote overall wellness.
At sufficient dosages, CBD will temporarily deactivate cytochrome P450 enzymes, thereby altering how we metabolize a wide range of compounds. With cannabidiol (CBD) poised to become widely available in pharmaceutical, nutraceutical, and herbal preparations, medical scientists are taking a closer look at CBD-drug interactions.
Cannabidiol is a safe, non-intoxicating, and non-addictive cannabis compound with significant therapeutic attributes, but CBD-drug interactions may be problematic in some cases.
CBD and other plant cannabinoids can potentially interact with many pharmaceuticals by inhibiting the activity of cytochrome P450, a family of liver enzymes. This key enzyme group metabolizes most of the drugs we consume, including more than 60 percent of marketed meds.
At sufficient dosages, CBD will temporarily deactivate cytochrome P450 enzymes, thereby altering how we metabolize a wide range of compounds, including tetrahydrocannabinol (THC), which causes the high that cannabis is famous for.
When THC or any other foreign compound enters the body, it is metabolized. This process is generally very complicated. Metabolizing something properly can involve multiple molecular pathways and various enzymes that enable the body to get rid of the compound (often done by adding something to the original compound). Or metabolism can entail breaking down a compound into a more basic molecule that the body then uses.
Products of a drug’s metabolism are called its metabolites. These metabolites can have very different properties than the initial drug. Ethanol, for example, owes some of its effects, including much of the hangover, to its two-step metabolism. The buildup of acetaldehyde in the liver—while ethanol is converted first to acetaldehyde and then to acetic acid—is a major reason for ethanol’s liver toxicity and the nausea and vomiting caused by excessive consumption.
THC metabolites contribute significantly to the effects of cannabis consumption. Eleven-hydroxy-THC (11-OH-THC), for example, is a THC metabolite that activates the CB1 cannabinoid receptor in the brain and induces a high more potently than THC itself. This means that the body’s metabolism of THC can make it more potent.
Cytochrome P450 enzymes contribute to the metabolism of drugs by oxidizing them, which generally means incorporating an oxygen atom into the drug’s molecular structure. Oxidation will usually make a compound more water soluble and therefore easier for the kidneys to filter out. Both steps in the metabolism of ethanol, mentioned above, and the conversion of THC into 11-OH-THC involve oxidation (though ethanol is not oxidized specifically by cytochrome P450).
Different routes of cannabinoid administration have different effects. Inhaled THC enters capillaries in the lungs, passes into general circulation through the pulmonary arteries, and quickly crosses the blood-brain barrier. When ingested orally, however, THC is absorbed in the small intestine and then carried to the liver, where it is metabolized by subclasses of cytochrome P450 (abbreviated CYP), specifically the CYP2C and CYP3A enzymes.
These liver enzymes also metabolize CBD, converting it into 7-OH-CBD and 6-OH-CBD. But there has been relatively little research into the properties of these CBD metabolites.
The way CBD interacts with cytochrome P450 is pivotal; in essence, they deactivate each other. Preclinical research shows that CBD is metabolized by cytochrome P450 enzymes while functioning as a “competitive inhibitor” of the same liver enzymes. By occupying the site of enzymatic activity, CBD displaces its chemical competitors and prevents cytochrome P450 from metabolizing other compounds.
The extent to which cannabidiol behaves as a competitive inhibitor of cytochrome P450 depends on how tightly CBD binds to the active site of the metabolic enzyme before and after oxidation. This can change greatly, depending on how—and how much—CBD is administered, the unique attributes of the individual taking this medication, and whether isolated CBD or a whole plant remedy is used.
If the dosage of cannabidiol is low enough, it will have no noticeable effect on CYP activity, but CBD may still exert other effects. There is no clearly established cut-off dose, below which CBD does not interact with other drugs. A 2013 report on a clinical trial using GW Pharmaceutical’s Sativex, a whole plant CBD-rich sublingual spray, found no interactions with CYP enzymes when approximately 40mg of CBD were administered. A subsequent clinical trial, however, found that 25mg of orally administered CBDsignificantly blocked the metabolism of an anti-epileptic drug.
How do CBD-generated changes in cytochrome P450 activity impact the metabolic breakdown of THC? Animal studies indicate that CBD pretreatment increases brain levels of THC. That’s because CBD, functioning as a competitive inhibitor of cytochrome P450, slows down the conversion of THC into its more potent metabolite, 11-OH-THC. Consequently, THC remains active for a longer duration, but the peak of the extended buzz is blunted somewhat under the influence of cannabidiol.
Other factors figure prominently in CBD’s ability to lessen or neutralize the THC high.
Lester Bornheim, a research pharmacologist at the University of California in San Francisco, was among the first scientists to study the metabolism of CBD. In 1987, he was awarded a NIDA grant to investigate the effects of phytocannabinoids on cytochrome P450 enzymes. THC and cannabinol (CBN) also inhibit CYPactivity, but CBD, of all the plant cannabinoids studied, is the strongest cytochrome P450 deactivator.
“It’s a very unusual enzyme. Almost all other enzymes are designed to fit a single substrate and carry out a single chemical process resulting in a single product,” Bornheim noted, whereas numerous drugs are substrates for cytochrome P450, which seems to function like a generic breakdown mechanism for a wide range of exogenous and endogenous substances.
In 1999, Bornheim addressed the annual gathering of the International Cannabinoid Research Society (ICRS) and drew attention to the possibility that CBD could interfere with the metabolism of many medications. A year earlier, a team of Canadian scientists identified certain compounds in grapefruit that inhibit the expression of some cytochrome P450 enzymes—which is why physicians often warn patients not to eat grapefruit before taking their meds. CBD, it turns out, is a more potent inhibitor of cytochrome P450 enzymes than the grapefruit compound Bergapten (the strongest of several grapefruit components that inhibit CYPs).
What does this mean in practical terms for a medical marijuana patient on a CBD-rich treatment regimen who takes a prescription blood-thinner like warfarin, for example? CBD reduces the enzymatic degradation of warfarin, thereby increasing its duration of action and effect. A person taking a CBD-rich product should pay close attention to changes in blood levels of warfarin, and adjust dosage accordingly as instructed by their doctor.
In cancer treatment, the precise dosing of chemotherapy is extremely important; doctors often struggle to find the maximum dose that will not be catastrophically toxic. Many chemotherapy agents are oxidized by CYPs before their inactivation or excretion. This means that for patients using CBD, the same dose of chemotherapy may produce higher blood concentrations. If CBD inhibits the cytochrome-mediated metabolism of the chemotherapy and dosage adjustments aren’t made, the chemotherapy agent could accumulate within the body to highly toxic levels.
By and large, however, there have been few reported adverse cannabinoid-drug interactions among the many cancer patients who use cannabis to cope with the wrenching side effects of chemotherapy. It is possible that whole plant cannabis, with its rich compensatory synergies, interacts differently than the isolated CBD that is administered in most research settings. As well, the cytoprotective effects of the cannabinoids may mitigate some of the chemotherapeutic toxicity.
Some epileptic patients have encountered issues with how CBD interacts with their anti-seizure medication. A small clinical study at Massachusetts General Hospital involving children with refractory epilepsy found that CBD elevated the plasma levels and increased the long-term blood concentrations of clobazam, an anticonvulsant, and norclobazam, an active metabolite of this medication. A majority of these children needed to have their dose of clobazam reduced due to side effects. Given that both clobazam and CBD are metabolized by cytochrome P450 enzymes, a drug-drug interaction is not surprising. Published in May 2015, the study concluded that “CBD is a safe and effective treatment of refractory epilepsy in patients receiving [clobazam].” But the report also emphasized the importance of monitoring blood levels for clobazam and norclobazam in patients using both CBD and clobazam.
Dr. Bonni Goldstein has observed cases in which small doses of high-CBD/low-THC cannabis oil concentrate seemed to aggravate seizure disorders rather than quell them. How could this happen, given CBD’s renown anti-epileptic properties?
A 1992 review by Lester Bornheim and his colleagues indicated that CBD inhibits some cytochrome P450enzymes at smaller doses than what is required for CBD to exert an anti-epileptic effect. This means that a certain dose of CBD could alter the processing of an anti-epileptic drug taken by the patient, but this amount of CBD might not be enough to provide any anti-epileptic relief itself. The advice some physicians offer in this situation may seem counterintuitive: Increase the dose of CBD—perhaps even add a little more THC (or THCA, the raw, unheated, non-psychoactive version of THC)—and this may be more effective for seizure control.
But why would preventing the breakdown of an anti-epileptic drug reduce its effect? There are a number of possible answers, depending on the drug in question. The active component of the drug (the chemical that exerts an anti-epileptic effect) may be a breakdown product of the actual drug taken. So, by slowing the metabolism of the original drug, CBD would make that drug less active.
Other explanations are conceivable. For example, if the activity of certain CYPs is slowed, the drug may be broken down by another metabolic pathway, the products of which could then interfere with the drug’s activity. Or perhaps the inhibition of CYPs is not the predominant way that CBD interacts with certain anti-epileptic medications.
To complicate matters even further, a presentation by Dr. Kazuhito Watanabe at the 2015 International Cannabinoid Research Society meeting in Nova Scotia disclosed preliminary evidence that cannabidiol may “induce”—meaning amplify the activity of—some cytochrome P450 enzymes. (Induction of a protein involves increasing the transcription of its corresponding mRNA, which leads to greater synthesis of the protein.) This suggests that CBD can either increase or decrease the breakdown of other drugs. Again, it depends on the drug in question and the dosages used.
Any pharmaceutical, nutraceutical or green rush scheme to exploit the therapeutic potential of CBD must reckon with the fact that cannabidiol can both inactivate and enhance various cytochrome P450 enzymes in the liver—and this can potentially impact a wide range of medications. Drug interactions are especially important to consider when using life-saving or sense-saving drugs, drugs with narrow therapeutic windows, or medications with major adverse side effects. In particular, those who utilize high doses of CBDconcentrates and isolates should keep this in mind when mixing remedies.